Depression is a persistent state of low mood, low energy or anhedonia and is considered a common mental disorder. It is associated with a wide range of significant emotional, psychological and physical symptoms. It can have a significant impact on people's functioning, and mental ill health is estimated to cost the UK economy ￡94 billion per year. An estimated 40 of GP consultations are about mental health, and it is important that depression is appropriately diagnosed and managed. This article reviews the most recent National Institute for Health and Care Excellence guidelines and also gives special consideration to managing depression alongside physical comorbidities and in patients from different cultures.
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