Association of genetic polymorphisms in DNA repair genes ERCC2 Asp312Asn (rs1799793), ERCC2 Lys 751 Gln (rs13181), XRCC1 Arg399 Gln (rs25487) and XRCC3 Thr 241Met (rs861539) with the susceptibility of lung cancer in Saudi population

SulimanAlsagaby; Ahmed A.Ahmed; ZafarRasheedSami A.AlthwabAbdullah S. M.AljohaniFahad A.AlhumaydhiHomaidan T.AlhomaidanAbdullah S.AlkhamissMohammadAlkhowailedAqeelAlaqeelMohamd A.AlblihedJihadAlrehailiNelsonFernándezWaleed AlAbdulmonem

首页> 外文期刊>Nucleosides, nucleotides and nucleic acids >Association of genetic polymorphisms in DNA repair genes ERCC2 Asp312Asn (rs1799793), ERCC2 Lys 751 Gln (rs13181), XRCC1 Arg399 Gln (rs25487) and XRCC3 Thr 241Met (rs861539) with the susceptibility of lung cancer in Saudi population

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Association of genetic polymorphisms in DNA repair genes ERCC2 Asp312Asn (rs1799793), ERCC2 Lys 751 Gln (rs13181), XRCC1 Arg399 Gln (rs25487) and XRCC3 Thr 241Met (rs861539) with the susceptibility of lung cancer in Saudi population

机译：DNA 修复基因 ERCC2 Asp312Asn （rs1799793）、ERCC2 Lys 751 Gln （rs13181）、XRCC1 Arg399 Gln （rs25487）和 XRCC3 Thr 241Met （rs861539）的遗传多态性与沙特人群肺癌易感性的关联

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Abstract This study demonstrated the association of polymorphisms in ERCC2 (Asp312Asn) rs1799793, ERCC2 (Lys751Gln) rs13181, XRCC1 (Arg399Gln) rs25487 and XRCC3(Thr241Met) rs861539 polymorphisms with a susceptibility of lung cancer (LC) onset in the Saudi population. The study was performed on 134 LC patients and 270 controls. The data revealed that there was no significant association of LC with subtype squamous cell carcinoma (SCC), small cell lung cancer (SCLC) and adenocarcinoma with the ERCC2 rs1799793 polymorphism. The data showed that the CC genotype for ERCC2 rs13181, the AA genotype for XRCC1 rs25487, and the genotype TT for XRCC3 rs861539 were significantly associated with SCC susceptibility (p?

机译：摘要本研究表明，ERCC2 （Asp312Asn） rs1799793、ERCC2 （Lys751Gln） rs13181、XRCC1 （Arg399Gln） rs25487 和 XRCC3（Thr241Met） rs861539 多态性与沙特人群肺癌（LC）发病易感性相关。该研究对 134 名 LC 患者和 270 名对照者进行了研究。数据显示，LC与亚型鳞状细胞癌（SCC）、小细胞肺癌（SCLC）和腺癌与ERCC2 rs1799793多态性无显著相关性。数据显示，ERCC2 rs13181的CC基因型、XRCC1 rs25487的AA基因型和XRCC3 rs861539的TT基因型与SCC易感性显著相关（p？0.05）。同样，ERCC2 rs13181 的 CC 基因型和 XRCC1 rs25487 的 AA 基因型与腺癌易感性显著相关（p？0.05）。而 XRCC3 rs861539 的 TT 基因型与 SCLC 易感性显著相关（p？=？0.005）。总的来说，在以下隐性基因型组合模型中发现了LC易感性的显着关联：ERCC2 rs13181？+的AC杂合子？XRCC1 rs25487 为 AA 纯合子，ERCC2 rs13181？+？GA 纯合子为 rs25487，rs13181？+？XRCC1 rs25487 为 AA 纯合子，ERCC2 rs13181？+？TT 为 XRCC3 rs861539 纯合子，XRCC1 rs25487？+？XRCC3 rs861539 的 CT 杂合子，XRCC1 rs25487？+？TT 的 GA 杂合子，XRCC3 rs861539 的 AA 杂合子，XRCC1 rs25487？+？XRCC3 rs861539 的 CT 杂合子，XRCC1 rs25487+ XRCC3 rs861539 的 AA 纯合子。这些数据清楚地表明，隐性基因型的组合可能与LC发病的易感性有关（p？0.05）。简而言之，数据表明，DNA修复基因通过基因-基因相互作用而不是独立变异来增加LC风险。

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《Nucleosides, nucleotides and nucleic acids》 |2022年第6期|530-554|共25页
作者
SulimanAlsagaby; Ahmed A.Ahmed; ZafarRasheedSami A.AlthwabAbdullah S. M.AljohaniFahad A.AlhumaydhiHomaidan T.AlhomaidanAbdullah S.AlkhamissMohammadAlkhowailedAqeelAlaqeelMohamd A.AlblihedJihadAlrehailiNelsonFernándezWaleed AlAbdulmonem;
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Department of Medical Laboratories Sciences, College of Applied Medical Sciences, Majmaah University;

Research Center, College of Medicine, Qassim University;

Department of Medical Biochemistry, College of Medicine, Qassim UniversityDepartment of Food Science and Human Nutrition, College of Agriculture and Veterinary MedicineDepartment of Veterinary Medicine, College of Agricultural and Veterinary Medicine, QassimDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim UniversityDepartment of Family and Community Medicine, College of Medicine, Qassim UniversityDepartment of Pathology, College of Medicine, Qassim UniversityDepartment of Dermatology, College of Medicine, Qassim UniversityDepartment of Pediatrics, College of Medicine, Qassim UniversityDepartment of Medical Microbiology, School of Medicine, Taif UniversityPathology Department, Imam Mohammad Ibn Saud UniversitySchool of Life Sciences, University of Essex;

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正文语种英语
中图分类生物化学;
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Genetic polymorphism; DNA repair genes; lung cancer; squamous cell carcinoma; adenocarcinoma; small cell carcinoma;

机译：遗传多态性;DNA修复基因;肺癌;鳞状细胞癌;腺癌;小细胞癌;

Association of genetic polymorphisms in DNA repair genes ERCC2 Asp312Asn (rs1799793), ERCC2 Lys 751 Gln (rs13181), XRCC1 Arg399 Gln (rs25487) and XRCC3 Thr 241Met (rs861539) with the susceptibility of lung cancer in Saudi population

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