Recent Advances in Organocatalytic Asymmetric Michael Addition Reactions to alpha, beta-Unsaturated Nitroolefins

摘要

An organocatalyzed asymmetric Michael addition reaction has been established as the most relevant and dynamic research area for the construction of chiral carbon-carbon and carbon-heteroatom bond. In the current scenario, rapid revolutions on asymmetric Michael addition to nitroolefins have been explored by taking advantage of newly developed chiral organocatalysts. Moreover, nitroolefins have proven as well-known Michael acceptors for providing various structurally essential nitro-functionalized frameworks. In addition to this, remarkable stereoselectivity has been achieved in this asymmetric process by following different mechanistic pathways that involve enamine, iminium ion intermediate formation and bifunctional H-bonding interaction. So, we have discussed the recent advancements of organocatalytic Michael addition reactions to alpha, beta-unsaturated nitroolefins from the year 2016 to 2020.