Aim Polypharmacy in elderly people is a social issue and has been reported to cause not only drug adverse events, but also falls, dysfunction and cognitive decline. Those events may trigger prolonged length of hospitalization. Therefore, the aim of this study was to investigate whether polypharmacy has a prolonging effect on hospitalization. Methods The study subjects were 584 patients in a university hospital in Japan who had been admitted for hepatectomy, pancreaticoduodenectomy, gastrectomy or colectomy, and to whom clinical pathways had been applied. In this study, polypharmacy was defined as taking five or more regular oral medications, and prolonged hospitalization was defined as hospitalization longer than that determined by the clinical pathway. Multiple logistic regression analysis was performed to investigate whether polypharmacy affects the length of hospitalization. Results The subjects were 348 males and 236 females, mean +/- SD age of 65.8 +/- 12.9 years. Among all subjects, 228 (39.0) were receiving polypharmacy at admission, and the number of patients with prolonged hospitalization was 262 (44.9). Multiple logistic regression analysis revealed that the following variables were significantly associated with prolonged hospitalization; polypharmacy (odds ratio = 1.532; 95 confidence interval = 1.010-2.327), age 50-59; 2.971 (1.216-7.7758), age 60-69; 2.405 (1.059-5.909), organ pancreas; 0.298 (0.122-0.708), operation time >= 386 min; 2.050 (1.233-3.432), intraoperative bleeding volume >= 401 mL; 2.440 (1.489-4.038), postoperative delirium; 2.395 (1.240-4.734), postoperative infection; 10.715 (4.270-33.059). Conclusion The current study revealed that polypharmacy at admission was an independent factor for prolonged hospitalization. In future, measures against polypharmacy are required, collaborating with outpatient clinics, family doctors and dispensing pharmacies.Geriatr Gerontol Int center dot center dot; center dot center dot: center dot center dot-center dot center dot Geriatr Gerontol Int 2020; center dot center dot: center dot center dot-center dot center dot.
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机译：目的 老年人多药治疗是一个社会问题，据报道，不仅会引起药物不良事件，还会导致跌倒、功能障碍和认知能力下降。这些事件可能会延长住院时间。因此，本研究的目的是调查多药治疗是否对住院治疗有延长作用。方法 选取日本某大学医院收治肝切除术、胰十二指肠切除术、胃切除术或结肠切除术的584例患者，并采用临床路径。在这项研究中，多药治疗被定义为服用五种或更多常规口服药物，长期住院被定义为住院时间超过临床路径确定的住院时间。采用多元logistic回归分析多元logistic回归分析是否影响住院时间。结果 受试者男性348例，女性236例，平均+/- SD年龄为65.8 +/- 12.9岁。在所有受试者中，228例（39.0%）在入院时接受多种药物治疗，长期住院的患者人数为262例（44.9%）。多元logistic回归分析显示，以下变量与住院时间延长显著相关;多药治疗（比值比 = 1.532;95% 置信区间 = 1.010-2.327），年龄 50-59 岁;2.971 （1.216-7.7758），60-69 岁;2.405 （1.059-5.909），胰腺器官;0.298 （0.122-0.708），操作时间 >= 386 min;2.050 (1.233-3.432）、术中出血量 >= 401 mL;2.440（1.489-4.038），术后谵妄;2.395（1.240-4.734），术后感染;10.715 (4.270-33.059).结论 本研究显示，入院时多药治疗是导致住院时间延长的独立因素。今后，需要与门诊诊所、家庭医生和配药药房合作，采取措施打击多药治疗。Geriatr Gerontol Int center dot center dot;中心点中心点：中心点中心点-中心点中心点Geriatr Gerontol Int 2020;中心点中心点：中心点中心点-中心点中心点。
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