Water-soluble polymeric forms of Rifabutin antitubercular drug, based on copolymers of acrylamide with 2-acrylamido-2-methylpropanesulfonic acid and of N-vinylpyrrolidone with 2-aminoethyl methacrylate, with ionic and covalent polymer-Rifabutin bonding were prepared. Polymeric carriers with the molecular mass of 7.5-98 kDa were prepared by radical copolymerization in alcohols at 60 degrees C; the hydrodynamic radii Rh-D of the polymer-Rifabutin complex and initial polymeric carrier were 2.6 and 2.35 nm, respectively. The Rifabutin content of the polymer systems was 14.1-43.4 mol %. The kinetics of the Rifabutin release from the polymeric forms in a model medium was estimated. Both types of the polymeric forms showed high activity toward M. smegmatis ATCC-607.
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