Changes in irisin, inflammatory cytokines and aerobic capacity in response to three weeks of supervised sprint interval training in older men

摘要

BACKGROUND: This study investigated the effects of supervised short-term sprint interval training (SIT) on circulating irisin, interleukin (IL) -6 and tumour necrosis factor (TNF)-a concentrations, and aerobic capacity and body composition values in healthy older men. METHODS: Eleven older men (63 +/- 8 years; 178.0 +/- 5.5 cm; 82.7 +/- 8.6 kg; 22.7 +/- 3.7% body fat) underwent SIT (6 repetitions of 30 s all-out cycling bouts with 4 min active recovery after each bout) three days a week for three consecutive weeks. Body composition measured by dual -energy X-ray absorptiometry, aerobic capacity assessed by direct peak oxygen consumption (VO2peak) test and morning fasting blood samples were obtained before and after a 3-week SIT intervention. RESULTS: Nine supervised SIT sessions moderately (effect size [ES] =0.65; P0.05) in body composition variables were observed after a short-term SIT period. CONCLUSIONS: A 3-week SIT intervention with only nine training sessions increased circulating irisin concentrations, improved inflamma-tory profile and aerobic capacity without changes in body composition in healthy older men. Accordingly, a short-term SIT programme is a time efficient alternative for traditional aerobic training to improve metabolic health and aerobic capacity in older adults.