With the introduction of cyclosporine a decade ago, the results of transplantation improved markedly. More recently, the use of multiple immunosuppressive drugs in sequential therapy has resulted in even better graft survival rates but has been associated with an increased incidence of lymphomas. Recent studies have shown improved growth in children treated with recombinant growth hormone after transplantation, and excellent patient and graft survival rates in infants who received transplants. In reports of pediatric transplants performed in the 1960s, 65% of the patients were alive 20–27 years later and most had good rehabilitation.
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