Brain-Targeted Exosomes-Based Drug Delivery System to Overcome the Treatment Bottleneck of Brainstem Glioma

摘要

Brain health is the humans’ primary goal in achieving health and longevity.Brainstem glioma (BSG) has a high disability and mortality rate, posing aserious threat to children’s brain health. Delivery of drugs to the brainstemis limited by poor tumor targeting and low blood-brain barrier (BBB)permeability. Thus, it is a great challenge to construct intracranial drugdelivery systems with strong biocompatibility, low immunogenicity, andhigh BBB permeability for the delivery of drugs targeting BSG. Exosomes,as the next generation of novel delivery systems, have been widely used toacross the BBB due to their advantages of good biocompatibility, stability,and permeability of the BBB and have made corresponding breakthroughsin targeted drug delivery for CNS diseases. This review summarizesnatural, polypeptide functionalized, and physical methods-assisted braintargetedexosomes-based drug delivery systems, the drug treatmentbottleneck of BSG, and highlights the potential of using a brain-targetedexosomes-based drug delivery system to overcome the drug treatmentbottleneck of BSG. It provides new insights into using exosomes-based drugdelivery for BSG treatment.