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机译:来自 MYL2-R58Q 介导的心尖肥厚型心肌病患者的诱导多能干细胞衍生的心肌细胞显示肥大、肌原纤维紊乱和钙扰动
Mayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut;
Mayo Clin, Dept Anat Pathol, Rochester, MN 55905 USA;
Mayo Clin, Dept Cardiovasc Med, Rochester, MN 55905 USAMayo Clin, Dept Cardiovasc Surg, Rochester, MN 55905 USA;
Hypertrophic cardiomyopathy (HCM); Myosin regulatory light chain (MYL2); R58Q; Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs); Disarray; Calcium transients; L-type Ca2+ channel (LTCC);