Anti‐H‐Y responses of H‐2bmutant mice

摘要

AbstractTwo strains of H‐2bmutant mice, H‐2baand H‐2bf, in which the mutational event took place at H‐2K, make anti‐H‐Y cytotoxic T cell responses which are H‐2‐restricted, Db‐associated and indistinguishable in target cell specificity from those of H‐2bmice. Thus, alteration of the H‐2K molecule affects neither the Ir gene controlling the response, nor the associative antigen. On the other hand, one H‐2Dbmutant strain, H‐2bo, although it makes a good anti‐H‐Y cytotoxic response, shows target cell specificity restricted to its own Dboantigen(s), and neither H‐2b, H‐2baor H‐2bfanti‐H‐Y cytotoxic cells kill H‐2bomale target cells. Thus, the alteration of the H‐2Dbmolecule does not affect the Ir gene of H‐2bmice, bu