...
首页> 外文期刊>BioEssays : >Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias: A hypothesis
【24h】

Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias: A hypothesis

机译:Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias: A hypothesis

获取原文
获取原文并翻译 | 示例
           

摘要

Could 10-20% of autism be prevented? We hypothesize that nonsyndromic or "essential'' autism involves extreme male bias in infants who are genetically normal, but they develop deficiency of carnitine and perhaps other nutrients in the brain causing autism that may be amenable to early reversal and prevention. That brain carnitine deficiency might cause autism is suggested by reports of severe carnitine deficiency in autism and by evidence that TMLHE deficiency - a defect in carnitine biosynthesis - is a risk factor for autism. A gene on the X chromosome (SLC6A14) likely escapes random X-inactivation (a mixed epigenetic and genetic regulation) and could limit carnitine transport across the blood-brain barrier in boys compared to girls. A mixed, common gene variant-environment hypothesis is proposed with diet, minor illnesses, microbiome, and drugs as possible risk modifiers. The hypothesis can be tested using animal models and by a trial of carnitine supplementation in siblings of probands. Perhaps the lack of any Recommended Dietary Allowance for carnitine in infants should be reviewed.

著录项

获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号