AbstractDisposition kinetics in goats of fenvalerate (RS)‐α‐cyano‐3‐phenoxybenzyl (RS)‐2‐(4‐chlorophenyl)‐3‐methylbutyrate were studied after oral administration at 5 mg kg−1. The insecticide persisted in blood for up to 48 h. TheVd(area),t1/2(β), andt1/2(Ka), of fenvalerate were 12.14 (±0.39) litre kg−1, 12.25 (±0.25) h and 0.63 (±0.11)h, while theAUCandClBvalues were respectively 7.35 (±0.39) μg h ml−1and 0.68 (±0.04) litre kg−1h−1. The residues in tissues reached a peak four days after insecticide administration and then started to decline. Maximum residue was found in the adrenal gland, followed by liver, kidney and intestine. Both GOT and GPT activities in kidney tissue, but only GPT activities in liver tissue had decreased significantly 4, 8 and 22 days post‐administration. The fenvalerate did not produce any significant effects on serum acetylcholinesterase, cholesterol or protein levels in goats. Histopathological examination showed fatty changes in the periphery of lobule, congestion in sinusoid, haemolysis in central vein, necrosis and periportal fibrosis around the central vein of liver, and necrosis i
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机译:摘要 以5 mg kg−1口服氰戊菊酯[(RS)‐α氰基‐3‐苯氧基苄基(RS)‐2‐(4‐氯苯基)‐3‐甲基丁酸酯]为研究对象。杀虫剂在血液中持续存在长达48小时。氰戊菊酯的Vd(面积)、t1/2(β)和t1/2(Ka)分别为12.14(±0.39)升kg-1、12.25(±0.25)h和0.63(±0.11)h,AUC和ClB值分别为7.35(±0.39)μg h ml-1和0.68(±0.04)升kg-1h-1。组织中的残留在给药后4天达到峰值,然后开始下降。在肾上腺中发现最大的残留物,其次是肝、肾和肠。GOT和GPT在肾组织中的活性均在给药后4、8和22天显著降低,但只有肝组织中的GPT活性显著降低。氰戊菊酯对山羊血清乙酰胆碱酯酶、胆固醇或蛋白质水平无显著影响。组织病理学检查显示小叶周边脂肪改变、鼻窦充血、中央静脉溶血、肝中央静脉周围坏死和门静脉周围纤维化、坏死I.型
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