In recent decades, the chemistry of functionally substituted 1,2,4-triazoles and the fused heterocyclic systems based on them have received significant attention due to their structural and biological characteristics. The 1,2,4-triazole ring is a fragment of many fungicides such as fluconazole, intraconazole, and voriconazole.1 3-R-4-Amino-l,2,4-triazole-5-thiones were found to exhibit antimicrobial and anti-inflammatory activity.2-5 Fused heterocyclic triazoles also possess important clinical applications;; thus, 1,2,4-triazolo[3,4-b][1,3,4]fhiadiazoles were reported as antiviral, antifungal, and antitumor agents.6-8 Anti-HIV activity was also found.9 Stericaliy hindered phenols were reported to possess anti-inflammatory and antimicrobial properties,10,11 in addition to their well-known antioxidant activity.12 As a continuation of our studies on the synthesis of azoles containing a hindered phenol moiety,13,14 in the present work we have synthesized a number of novel compounds: substituted arylideneamino-2,4-dihydro-3H-1,2,4-triazole-3-fhiones, l,2,4-triazolo[3,4-b][1,3,4]-thiadiazoles and 6-aryl/alkyl-amino[l,2,4]-triazolo[3,4-b][l,3,4]thiadiazoles, based on 3-(4-hydroxy-2,6-di-tert-butylphenyl) propanoic acid hydrazide, in search of new structures potentially exhibiting useful properties.
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