Synthesis of New 2-Aryl-4-1,2-bis(dialkoxyphosphoryl)vinyl-5-ethoxy-1,3-oxazoles

摘要

A series of new substituted phosphonylated 1,3-oxazoles, 2-aryl-4-[1,2-bis(dialkoxyphosphoryl)vinyl]-5-ethoxy-1,3-oxazoles, was obtained by the reaction of ethynyldiphosphonic acid tetramethyl ester with diethyl 2-aroylaminomalonates. The reaction proceeds stereoselectively with the intermediate formation of the corresponding Z-2-aroylamino-2-[1,2-bis(dialkoxyphosphoryl)vinyl]malonates.