A tympanic membrane perforation is more than simply a hole in the eardrum — it causes or augments hearing loss, significantly reducing a patient's quality of life. The impact of problems resulting from communication disorders should not be underestimated. In this paper, we introduce office-based growth factor enabled eardrum repair. Advances in tissue engineering have delivered a major breakthrough in the treatments available: The development of a therapy involving the body's self-repair system. The tympanic membrane has a natural capacity to regenerate. Elucidating and understanding the mechanism of this regeneration has inspired the development of a safer and more convenient therapy, which may be well tolerated by patients. This treatment involves enlarging perforations and providing a gelatin sponge impregnated with basic fibroblast growth factor as a substrate. ? 2021 The Author(s)
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