A possible mechanism for chemical induction of chromosome aberrations in male meiotic and postmeiotic germ cells of mice

摘要

The mechanisms by which chemically induced lesions in the chromosomes of mammalian germ cells are actually converted to aberrations and transmitted to progeny are very complex and little understood. An attempt is made to explain how dominant-lethal mutations and heritable translocations are produced from chemical treatment of meiotic and postmeiotic germ cells of male mice.