Differential expression of type I insulin‐like growth factor receptors in different stages of human T cells

摘要

AbstractInsulin‐like growth factor I (IGF‐I) has been implicated to play a regulatory role in T cell development and in T cell function. We investigated the expression of type I IGF receptors on human peripheral T cells related to the maturation and activation stage using the type I IGF receptor‐specific monoclonal antibody αIR3. It appeared that 87% of the CD4+CD45RA+cells and 66% of the CD8+CD45RA+cells were αIR3+, whereas only 37% of the CD4+CD45RO+cells and 38% of the CD8+CD45RO+cells bound αIR3. We also found that the fraction of αIR3+cells withinin vivo or in vitroactivated (HLA‐DR+) T cells is markedly lower than in nonactivated (HLA‐DR−) cells.In vitrophytohemagglutinin‐activated T cells and CD4+CD45RO+cells activated with recall antigens also contained less αIR3+cells (1–6%) than nonacti