Method of Preparation: Calculate the required quantity of each ingredient for the total amount to be prepared. Accurately weigh or measure each ingredient. Add the ketoconazole and the polyethylene glycol (PEG) 300 to a beaker; heat to 80°C for 30 minutes and spin until dissolved. Allow the mixture to cool with continued stirring. Slowly add bacteriostatic 0.9% sodium chloride solution to final volume with continued stirring. Dispense in metered nasal spray pump and label.
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