Clinical and cytogenetic findings have been described in a family in which the mother had given birth in three successive pregnancies at the ages of 24, 28 and 30 years respectively to a child with the Klinefelter syndrome (44/XXY), a normal male (44/XY) and a daughter with the Langdon Down anomaly, with a translocation within the 21–22 group of chromosomes. No translocated chromosome was found in any other member of the family. All three children had different father
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