Amoxicillin added to omeprazole prevents relapse in the treatment of duodenal ulcer patients

摘要

Objective:To evaluate two different therapies, omeprazole/amoxicillin versus omepra-zole alone, in the treatment of duodenal ulcer patients with respect to eradication ofHelicobacter pyloriand time in remission during a 6-month follow-up after cessation of therapy.Design:Double-blind, randomized, parallel groups.Setting:Outpatient referrals in nine Swedish centres.Patients:This study included 248 patients with active duodenal ulcer.Main outcome measures:Endoscopic and symptomatic evaluation of time in remission. Culture, histology and serology for determination ofH. pyloristatus.Results:Eradication ofH. pyloriwas 54 compared with 4% and the proportion of patients in remission at 6 months was 70 compared with 36% in the omeprazole/amoxicillin treated group versus the group treated with omeprazole alone. Of the patients who becameH. pylori-negative, 84% were in remission throughout the study.Conclusion:H. pyloriis an almost obligate prerequisite for duodenal ulcer disease. Amoxicillin added to omeprazole nearly doubled the proportion of patients in remission at 6 months follow-up. The eradication rate ofH. pyloriin patients with excellent compliance was 74%.