Biocatalytic methods have shown to be a versatile choice for obtaining a large number of organic compounds under a non-natural reaction condition. Another efficient approach is the continuous-flow system, which when combined with enzyme catalysis can make the process even more environmentally friendly. Based on this, amides from ethyl 3-(4-hydroxyphenyl) propanoate were obtained, catalyzed by Lipase B of Candida Antarctica (CAL-B) (41 %-75 %, 6-24 h) or in a free solvent/catalyst system (69-99 %, 72 h). The efficiency of amide synthesis was improved using a continuous-flow system, reducing the reaction time to 10 min of residence in presence of CAL-B. These results represent a contribution to the sustainable synthesis of compounds with cosmetic potential and pharmacological properties.
展开▼
