AbstractThe WHO database of the Collaborating Programme for International Drug Monitoring, which currently contains data from 31 countries, was reviewed for all drug/Stevens‐Johnson syndrome associations. The total number of such reports was 1707, involving 106 medicines with three or more reports per drug. From this, 22 previously unreported signals were found. The average delay from the first report to a stronger signal involving three reports was 4.4 years, delay usually being due to confounding by other medicines excluding some reports from being included in the signal. Reports from, on average, 2.8 countries were required to make a signal, and it is concluded that the international database allows for an expedient way of finding strong adverse drug reaction signals of rare event
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