Detection and localization by the monoclonal antiinterleukin 2 receptor antibody AMT‐13 of IL 2 receptor‐bearing cells in the developing thymus of the mouse embryo and in the thymus of cortisone‐treated mice

摘要

AbstractDuring embryonic development of the mouse, before expressing classical T cell markers, the blast cells colonizing the thymus react with the monoclonal antibody AMT‐13 shown previously to detect interleukin 2 receptors. The proportion of AMT‐13+cells decreases as gestation time increases. On the other hand, the proportion of Thy‐1+, Lyt‐1+and Lyt‐2+cells increases during ontogenesis. On the 19th day of gestation when the thymus architecture is comparable to the adult thymus, the AMT‐13+cells become localized in the subcapsular area of the cortex. In the adult thymus after cortison treatment the regenerating cells express the AMT‐13 antigen. The AMT‐13 antigen presumably the interleukin 2 receptor is the first marker of the early embryonic thymocytes reported until now that may be related to ce