Inactivation of Viruses during Ultraviolet Light Treatment of Human Intravenous Immunoglobulin and Albumin

摘要

AbstractA comparison of ultraviolet (UV) irradiation at two wavelength ranges UVB (280–320 nm) and UVC (lower than 280 nm) showed that UVC in particular could very effectively inactivate, in intravenous immunoglobulin (IVIG) and albumin preparations, non‐enveloped and non‐acid labile model viruses (i.e. Polio 2 and T4 phage) and dry heat‐resistant viruses (vaccinia and T4 phage). This effective virucidal treatment (5 min, 5,000 J/m2dose) was achieved before an unaceeptable level of WIG aggregates occurred. The use of UV irradiation to inactivate infectious agents could add safety and supplement current methods, e.g. solvent/detergent, low pH, which do not inactivate non‐enveloped, non‐acid labile or dry‐heat‐resistant vir