Over the past 30 years increasing numbers of molecules have been developed for treatment of multiple sclerosis. However, given the heterogeneity of the disease and the fact that many patients have refractory or progressive multiple sclerosis, new therapeutic alternatives are still needed. Tyrosine kinases are enzymes that mediate phosphorylation of tyrosine residues on downstream molecules that participate in signalling pathways. These kinases have crucial roles in cellular proliferation and differentiation, cell growth and metabolism, and survival and apoptosis, making them potential therapeutic targets in various autoimmune and lymphoproliferative diseases. Bruton's tyrosine kinase is a cytoplasmic tyrosine kinase expressed by B cells and myeloid cells.
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机译：在过去的 30 年里，越来越多的分子被开发用于治疗多发性硬化症。然而，鉴于该疾病的异质性以及许多患者患有难治性或进行性多发性硬化症的事实，仍然需要新的治疗替代方案。酪氨酸激酶是介导参与信号通路的下游分子上酪氨酸残基磷酸化的酶。这些激酶在细胞增殖和分化、细胞生长和代谢以及存活和凋亡中起着至关重要的作用，使其成为各种自身免疫性和淋巴组织增生性疾病的潜在治疗靶点。布鲁顿酪氨酸激酶是一种由 B 细胞和骨髓细胞表达的细胞质酪氨酸激酶。
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