Inflammation in the early phase after kidney transplantation is associated with increased long‐term all‐cause mortality

摘要

Abstract In the general population, low‐grade inflammation has been established as a risk factor for all‐cause mortality. We hypothesized that an inflammatory milieu beyond the time of recovery from the surgical trauma could be associated with increased long‐term mortality in kidney transplant recipients (KTRs). This cohort study included 1044?KTRs. Median follow‐up time post‐engraftment was 10.3?years. Inflammation was assessed 10?weeks after transplantation by different composite inflammation scores based on 21 biomarkers. We constructed an overall inflammation score and five pathway‐specific inflammation scores (fibrogenesis, vascular inflammation, metabolic inflammation, growth/angiogenesis, leukocyte activation). Mortality was assessed with Cox regression models adjusted for traditional risk factors. A total of 312 (29.9%) patients died during the follow‐up period. The hazard ratio (HR) for death was 4.71 (95% CI: 2.85–7.81, p?