AbstractThe thoracic duct lymphocyte (TDL) output from nude mice was 5–6 times lower than that from CBA mice during the first 24 h of drainage. Labeled TDL from nude mice (a virtually pure population of B cells) and from CBA mice (containing about 85 % T cells and 15 % B cells) were injected into nude and CBA recipients, respectively, in which thoracic duct fistulas had been established. The recovery of labeled cells in the lymph was 40 – 70 % for CBA TDL was studied and the results suggested that B cells homed predominanlty to the spleen and tended to remain there, whereas those T cells that had a much slower tempo than can T cells. The homing of51Cr‐labeled nude and CBA TDL was studied and the results suggested that B cells homed predominanlty to the spleen and tended to remain there, whereas those T cells that had initially lodged in the spleen subsequently migrated to the lymph nodes. There was a linear relationship between the appearance of labeled cells in the lymph and the period of time during which tritiated thymidine had been administered thrice daily to nude and to CBA mice. It could be calculated from the curves obtained in these mice that the potential average life‐span of B cells was of the order of 8 weeks and of T cells of 1
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