We examined HLA-DR genotype risks in 288 patients with rheumatoid arthritis who were carefully categorized for disease severity. Five hundred ethnically-matched bone-marrow donors were controls. A hierarchy of positive allelic associations was noted with DRB1~*0401 (p < 10~(-38)), ~*0404,8 (p < 10~(-43)), ~*0405 (p < 10~(-8)), ~*10 (p < 10~(-3)) and ~*0101,2 (p < 10~(-2)), while DRB1~*0403 was negatively associated (p = 0.02). The DRB1 genotype relative risks (and 95% Cls) for RA were: ~*0404,5,8/~*0404,5,8 = 36.2 (15-87), ~*0401/~*0404,5,8 = 31.3 (18-55), ~*0401/~*0401 = 18.8 (11-35), ~*0101,2/~*0404,5,8= 6.0 (2-14), ~*0101,2/~*0401 = 6.4 (3-12), ~*0101,2/~*0101,2 =1.3 (0.3-6), ~*10/~*0404,5,8 = 27.8 (5-148), ~*10/~*0401 = 20.8 (5-89), ~*10/~*0101,2 = 22.3 (5-96), ~*0404,5,8/DRX= 5.0 (3-8), ~*0401/DRX=4.7 (3-7), ~*0101,2/DRX= 2.3 (1.4_4), ~*10/DRX=3A (0.8-14). No significant correlation of DRB1 genotypes was found with severity of RA as judged by nodules or articular erosions.
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