An Improved Method for the Preparation of Intermediate‐Purity Antihemophilic Factor Concentrate for Therapeutic Usage

摘要

Abstract.An improved method involving pH changes in the process for the preparation of intermediate‐purity antihemophilic concentrate offers several advantages over the standard method. Antihemophilic concentrates thus prepared are more soluble, more purified and more stable than the standard antihemophilic concentrates. High‐potency antihemophilic concentrates with good solubility may be obtained by concentrating the [in‐process] solution before lyophiliz