BACKGROUNDndash;To correlate the serum tumor necrosis factor-agr; (TNFagr;) concentrations before, during and following plasma exchange in patients with Guillain-Barreacute; syndrome (GBS). In this prospective study, 21 GBS patients were selected. Patients in clinical stages III to V were subjected to plasma exchange. The control group included equal numbers of age-matched patients with other neurological diseases and healthy voluntary blood donors. A sandwich ELISA method was applied to estimate serum TNFagr; concentrations in test and control groups.REVIEW SUMMARYndash;Twelve GBS patients had elevated serum TNFagr; levels that ranged between 74 and 182 pg/mL. All 12 GBS patients showed a steady decrease in the TNFagr; concentration following plasma exchange and also showed a positive correlation with neurological recovery.CONCLUSIONSndash;We conclude that serum TNFagr; concentrations are elevated in 57.1percnt; of GBS patients and TNFagr; level decreases following plasma exchange.
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