Molecular Genetic Analysis of the ABO Blood Group System: 2.cis‐AB Alleles

摘要

AbstractWe have determined the nucleotide sequence of the coding region in the last two coding exons of ABO genes from twocis‐AB individuals (genotypecis‐AB/O) with no consanguinity. In this region,cis‐AB alleles from these 2 individuals were identical to one another while different from the A1allele by two nucleotide substitutions. Both of these nucleotide substitutions result in amino acid substitutions. The first substitution is identical to the one previously found in the A2allele. The other substitution is found at the fourth position of the four amino acid substitutions which discriminate A1and B transfe