The relationship between microtubules and the lipoprotein pigment found in senile Cynomolgus brain and senile human brain biopsy material was investigated. Numerous microtubules were present in all parts of the cytoplasm and within the pigment areas, running parallel or obliquely to the pigmet bodies and being associated with its lateral aspects. Microtubules also occurred in the periphery of neurons or appearing to enter the perineuronal oligodendrocytes. These observations indicate a possible role of microtubules in the transport of pigment bodies. The oligodendrocyte from human brain biopsy material has definitely taken the role of a phagocyte in ingesting pigment bodies. Its numerous microtubules may offer a fast moving system for disposing off pigment residues to the capillary endothelium.
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