Benign fibro-osseous tumors of bone: clinicopathological findings and differential diagnosis

摘要

? 2022Benign fibro-osseous tumors of the skeleton are a diverse group of neoplasms with overlapping histologic features. They are characterized by an admixture of fibroblast-like spindle cells enmeshed in a collagenous stroma admixed with varying quantities of bone that can be deposited in different configurations. Some fibro-osseous tumors are predisposed to develop in specific bones, while others can arise in any bone; they may be solitary or multicentric. The treatment is based on their biological behavior and ranges from observation and medical therapy to surgical removal. Prognosis depends on the extent of the disease and the biological potential of the neoplasm. Because of overlapping clinicopathological features distinguishing one fibro-osseous tumor from another can be difficult and requires correlation with the imaging and clinical findings. This review discusses the features of benign fibro-osseous tumors of the skeleton and their important differential diagnoses.