Idiotypic characteristics of λ1‐bearing anti‐α(1→3)dextran response in wild mice: high frequency of responder strains and co‐expression of IdI 558 and IdI 104 on the same molecule

摘要

AbstractIn laboratory mouse strains, only mice with the IghCaphenotype are able to mount an immune response against the α(1→3) glycosidic linkage of the B1355 dextran. The response is highly restricted with respect to utilization of only Vγ1and a few related members of the VH558 family, and characterized by the production of cross‐reacting (IdX), and individual (IdI) 104 and 558 idiotopes. We report in this study data showing a large degree of polymorphism in the anti‐α(1→3)Dex response among 35 wild‐derived mouse strains belonging to 4 different species. In contrast to the anti‐α(1→3)Dex response of common laboratory strains, neither this response nor expression of the IdX, and IdI 104 and 558 idiotopes are linked to the IghCahaplotype. We also demonstrate co‐expression on the same molecule of IdI 104 and IdI 558 idiotopes in wild mouse‐derived hybridomas. These data challenge the idea of the exclusive expression at the molecular level