AbstractA chronic suppression of Igh‐1b and Igh‐3b (IgG2aand IgG2bof b haplotype) allotype expression has been induced by injecting T splenocytes from normal BALB/c or BC8 mice into newborn F1hybrids of appropriate Igh congenic strains: BALB/c into (BALB/c Igha× CB20 Ighb)F1and BC8 into (BC8 Igha× C57BL/6 Ighb)F1or (C57BL/6 × BC8)F1. This suppression does not affect IgM (Igh‐6b) or IgA (Igh‐2b) expression. When the Ighbhaplotype is paternally transmitted, the proportion of T splenocyte recipients showing allotypic suppression increases with time reaching 70% 40 weeks after birth. We also succeeded in inducing this pattern of suppression in 2 out of 13 cases when the Ighbwas inherited from the mother. These normal T splenocytes are therefore clearly allotype specific. As Igh‐6b production is not affected by the suppression, these T splenocytes are believed to influence B cells more or less committed to Igh‐1b or Igh‐3b production rather than more precocious Igh‐6b (IgM of b haplotype) carrying precursors in the classical IgM‐I
展开▼
