Site‐dependent differences in rejection of tumor cells with and without preimmunization

摘要

AbstractDBA/2 mice were immunized subcutaneously (s.c.) and intraperitoneally (i.p.) against DBA/2 derived SL2 lymphoma cells.I.p. immunization causes i.p., but not s.c. immunity. However, s.c. immunization results in both s.c. and i.p. immunity, the latter being as strong as after i.p. immunization. Thus, we obviously have to prefer s.c. to i.p. immunization.The difference between i.p. and s.c. immune surveillance is discussed.