Red Cell Antigens P (Globoside) and Luke: Identification by Monoclonal Antibodies Defining the Murine Stage‐Specific Embryonic Antigens ‐3 and ‐4 (SSEA‐3 and SSEA‐4)1

摘要

Abstract.Two globoseries antigens (antigens borne on carbohydrate chains containing globoside), SSEA‐3 and SSEA‐4, were found on the red cells of the majority of people, but were absent from cells of rare p and Pkindividuals which lack globoside. In addition, SSEA‐4 was absent from red cells of Luke(‐) individuals which nevertheless express the P antigen (globoside) and SSEA‐3. The name LKE is proposed for the red cell antigen detected by the Luke serum and by MC813–70, the monoclonal antibody defining SSEA‐4. Among the LKE+ individuals, a few showed relatively weak expression of the antigen and were grouped separately as a LKE weak (LKEw) phenotype. Using MC813–70, the frequencies of the 3 phenotypes LKE+, LKEw and LKE‐ in an English donor population are 0.914, 0.072 and 0.