Abstract The ability for stem cell therapy in degenerative diseases and the replacement of organs has shown promising results in preclinical research. However, its therapeutic use remains limited even after several years of study. There is currently no single product or protocol based on stem cell therapy. Nanotechnology has shown tremendous potential and gained momentum in stem cell research and therapy due to its several characteristics like tunnel effects, quantum size effects, scale, and surface effects. Its importance is now being recognized specifically in the conformity, replication, and differentiation of stem cells. It has always been an area of interesting study for tissue engineering and regenerative medicine. Although there are many possibilities that nanotechnology may improve cell therapy and stem cell technology, still there are many cytotoxic threats, affecting the viability, stem cell differentiation, etc., that are associated. In this paper, some of the advancements and viewpoints on the use of nanotechnology in stem cell research and stem cell therapy have been discussed along with the application of nanoparticle in isolation tracking, regulation, and enhancing retention of stem cells. The article also discusses the problems, implementations, and challenges in the field that would strengthen the viewpoint and open up new directions/paths for future studies in the field.
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