In the high intensity areas, the application of interlayer spacing technology can achieve the unity of quality and seismic performance of high-rise buildings with enlarged base and multiple tower layers. Through the comparison and analysis of the structural schemes of an enlarged base multiple tower-layer high-rise building, the ultimate seismic isolation scheme was adopted, and its seismic response and seismic performance were analyzed and studied. The results show that the overall seismic isolation effect of the story isolation technique is good, which can greatly reduce the seismic response, and is an effective means to improve the seismic safety of the structure. Considering the structural characteristics of the project, the improvement of the economy and the quality of the building, the use of story isolation technique in the enlarged base multiple tower-layer structure in the high-intensity region is an optimal scheme. Finally, several key technical issues such as the combined seismic isolation scheme of the enlarged base story isolation technique and the additional bending moment of the isolator and the tensile device of the isolator were discussed, which can provide some references for similar engineering practices.
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