The effect of six weeks of nisoldipine therapy (10 mg qd) on the hemodynamic response to exercise and effort tolerance was studied in eight patients with uncomplicated essential hypertension. At rest, nisoldipine therapy significantly (P .01) reduced systolic (by 20 mm Hg, or 12%) and diastolic (by 12 mm Hg, or 13%) blood pressures. During submaximal static and dynamic exercise, nisoldipine failed to modulate the magnitude of the rise in blood pressure from resting values but did succeed in maintaining systolic and diastolic blood pressures at significantly reduced levels. The hypotensive action of nisoldipine was not accompanied by a significant reflex tachycardia, and the rate‐pressure product tended to be attenuated by nisoldipine, particularly during dynamic exercise (.05 P .1). Long‐term nisoldipine therapy did not modify subjective ratings of perceived exertion, the ventilatory anaerobic threshold, maximal oxygen consumption, or maximal exercise performance. This study concludes that nisoldipine is an antihypertensive agent beneficial not only at rest but also during static and dynamic exercise. The present data further demonstrate that nisoldipine's usefulness is not limited by an impaired effort tolerance in hypertensive patients.
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