Oligotyping of Italian celiac patients with the 11th International Histocompatibility Workshop reagents*

摘要

Abstract:Oligotyping for HLA‐DRB1, DQA1 and DQB1 specificities has been performed on PCR‐amplified DKA from 55 Italian celiac children, living in Rome. and 50 blood donors. 52.6% of CD patients were DR3;DQ A1 *0501; DQB 1 *0201 ‐positive versus 14% of controls (RR = 6.85) and 34.5% were DR5,7;DQA1*0501;DQB1*0201‐positive versus 2% of controls (RR = 25.86). 7 patients (12.7%) were negative for the DQA1 *0501/B1 *0201 dimer: 3 of them were DR4 (5.4%) and the others typed as DR1,5; 1,7: 5,7 and w6,7. No patient was negative for both DQA1*0501 and DQB1*0201