Improved Synthesis of First Cell-Permeable Allosteric PTPRZ Inhibitor NAZ2329

摘要

NAZ2329 is the first cell-permeable small molecular allosteric inhibitor of protein tyrosine phosphatase receptor-type Z (PTPRZ), which was considered as a new potential molecular target for drug development in glioblastoma. A facile and high-efficient synthesis of NAZ2329 was developed by a straight-forward strategy starting from key ethoxy benzyl bromide intermediate obtained from commercially available 4-(trifluoromethyl)phenol.