A new differentiation antigen of plasma cells

摘要

AbstractA cell‐surface differentiation antigen of mouse Ig‐secreting cells, MSPCA (Mouse‐specific plasma cell antigen), is identified by rabbit antiserum to mouse myeloma MOPC‐104E (which secretes λμ) or myeloma MPC‐67 (which secretesKα); these two antisera contained little or no anti‐Ig antibody.Although a11 5 mouse myelomas tested were MSPCA+, rabbit antisera to one of them, myeloma MOPC‐7OA, contained anti‐Ig antibody and little or no anti‐MSPCA. This myeloma differs from myelomas MOPC‐104E and MPC‐67 in that the Ig components it makes,Kγ1, are readily demonstrable on the cell surface.These results suggest that rabbits immunized with myeloma cells may respond by producing preferentially either anti‐MSPCA or anti‐Ig antibody, depending on the surface Ig‐phenotype of th