Recently, the development of several strategies based on immunotherapy has raised hopes for a more promising way to treat cancer patients. Here, we describe how interleukin (IL)-10, a seemingly unlikely candidate, stimulates the immune system in a particularly efficacious way. IL-10, an omnipotent anti-inflammatory cytokine, delivers an equally potent immune stimulation in the context of CD8~+ T cells and tumor immunity. By activation of tumor-resident, tumor-specific CD8~+ T cells, pegylated IL-10 can induce rejection of large and metastasizing tumors in mice. Here, we summarize the mechanisms of action of IL-10, the reasons why the mechanisms may be crucial for the treatment of cancer patients, and the rationale for applying pegylated IL-10 in theclinic.
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机译：最近，基于免疫疗法的几种策略的发展为治疗癌症患者提供了一种更有希望的方法带来了希望。在这里，我们描述了白细胞介素 （IL）-10（一种看似不太可能的候选者）如何以一种特别有效的方式刺激免疫系统。IL-10 是一种无所不能的抗炎细胞因子，在 CD8~+ T 细胞和肿瘤免疫的背景下提供同样有效的免疫刺激。聚乙二醇化的IL-10通过激活肿瘤驻留的肿瘤特异性CD8~+ T细胞，可诱导小鼠对大肿瘤和转移性肿瘤的排斥反应。在这里，我们总结了IL-10的作用机制，这些机制可能对癌症患者的治疗至关重要的原因，以及在临床上应用聚乙二醇化IL-10的基本原理。
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