ABSTRACTThe wound healing process was histopathologically investigated in a rabbit femoral artery (n= 48) after transection using a laser bipolar dissector (LBD, 1064nm the Nd:YAG bipolar contact laser) with laser power of 13W in 0.5-sec pulses. The cutting edges were harvested immediately (n= 6) and at 1 (n= 6), 4 (n= 6), and 7 (n= 6) days, 2 (n= 6), 3 (n= 6), and 4 (n= 6) weeks, and 6 months (n= 6), and evaluated by light microscopy. During the postoperative period, no perforation was seen in the 48 transected sites with the LBD. The healing process after LBD transection was accomplished within 2 weeks by organization of the intraluminal thrombus and by the formation of granulation tissue outside the adventitia of vessels. Characteristic morphological changes after LBD transection were recognized in the tapering area, i.e., cartilage and bone formation. Cartilaginous foci (n= 6) were observed in the media at 4 weeks after transection, and osseous foci (n= 3) in subendothelial space at 6 months. These observations may suggest that the heterotopic cartilaginous and osseous metaplasia of a vessel wall may be a result of the biostimulative effects of the Nd:YAG laser.
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