Possible Genetical Pathways for the Biosynthesis of Blood Group Mucopolysaccharides

摘要

AbstractThis paper put forward possible biosynthetic pathways for the formation of the blood group A, B, H and Lewis antigens based on the limited knowledge of their chemistry and genetics that was available in 1959. The schemes proposed that genes at four independent lociABO, HH, LeleandSexinteracted to give the five specificities A, B, H, Leaand Lehfound in secretions and that the primary products of the blood group genes were not the antigens but enzymes that catalysed the sequential addition of single sugars to complete the determinants.