A high - performance liquid chromatographic method for the determination of alfuzosin in human plasma has been developed and validated. A column-switching procedure without extraction was used to isolate the drug from biological matrix prior to the quantitative analysis. The lower limit of detection for the analyte was 1 ng/ml. The method was linear from 2 to 150 ng/ml for human plasma. Within- and between-assay precision and accuracy were all found to be 5.2% at the eight concentrations evaluated. This procedure, simple and rapid, is suitable for pharmacology studies on alfuzosin.
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