TRANSITION METAL-CATALYZED HYDROSILYLATION OF CARBONYL COMPOUNDS AND IMINES.A REVIEW

摘要

Reduction of carbonyl and pseudo-carbonyl functions represents a ubiquitous protocol in organic synthesis.Transition-metal catalysis has been successfully applied to the reduction of olefins,alkynes and many carbonyl compounds via hydrogenation or hydrosilylation.Hydro-genation reactions often proceed in good yields but only under high pressure or elevated temperature.In contrast,since the first report of metal-catalyzed hydrosilylation of ketones in the presence of Wilkinson's catalyst,smooth reaction conditions have been devised and in consequence over-reduced products are rarely detected.