Assignment of a processed mouseiAprt/ipseudogene to the same chromosome as the functional gene

摘要

A novel genetic system has been used to demonstrate that a processed adenine phosphoribosyltransferase (Aprt) pseudogene is located on mouse chromosome 8, which is the same chromosome that carries the functional Aprt gene. A restriction fragment length polymorphism associated with the pseudogene was found to segregate concordantly with chromosome 8 in APRT–/sup> mutants of a near-diploid cell line that had lost one copy of the chromosom