Abstract.Cytotoxic antisera against HL‐A antigens were tested in panels of Caucasian, Bantu and Indian donors. A serum that gives reliable results in Caucasians may prove quite unreliable when used in Bantu or Indians, since it may possess extra antibodies against antigens that are very rare in Caucasians but common in the other groups. Every serum that is to be used in a population different from that in which it was standardized must therefore be re‐standardized in the new group before use. Results obtained in previous studies by EDTA agglutination cannot be compared with those obtained by cytotoxicity. The NIH serum Willett (anti‐HL‐A 8) gives identical results by agglutination and by cytotoxicity when tested in Caucasians; but in the Bantu it reacts with 49% by agglutination and only 8% by cytotoxicity. The Bantu evidently possess several unidentified HL‐A
展开▼
